This text is devoted to the enzyme heme oxygenase, which cleaves heme to produce carbon monoxide, biliverdin, and free iron, all important bioactive molecules. Chapters discuss the two isozymes, heme oxygenase-1 and -2, and their roles in human disease. Topics covered include;
inflammation and immunity, transplantation, ischemia reperfusion injury, angiogenesis, iron homeostasis, and other areas of molecular biology. The role of HO-1 in the regulation of cardiovascular function and many other diseases, such as sickle cell disease, is also discussed.
This new book brings together leading research from around the world. The preface, titled ‘The Cain Mutiny’, stands apart from the molecular nitty-gritty, telling the story of a dog named Cain that survived a lethal dose of carbon monoxide at a St Louis pound. Preface author and editor Leo Otterbein uses the anecdote to introduce the spirit of iconoclasm and discovery that the research in the book represents.
Other recent publications
Chemistry and Biology of Heparin and Heparan Sulfate
Hari G. Garg, Robert J. Linhardt, and Charles A. Hales
Elsevier Press publishing
Almost 90 years after its discovery, heparin and its derivatives remain important drugs in clinical practice. Yet it was not until recently that the scientific community came to understand the macromolecule’s anticoagulant activity. In this text, Hari Garg, HMS principal associate in medicine at Massachusetts General Hospital; Robert Linhardt, professor at the Rensselaer Polytechnic Institute; and Charles Hales, HMS professor of medicine at MGH, explain the chemistry, biology, and clinical applications of heparin and heparan sulfate, as well as their function in various physiological and pathological conditions.The No Sweat Exercise Plan: Lose Weight, Get Healthy, and Live Longer
Harvey B. Simon
McGraw–Hill publishing
For many, exercise is a guilty afterthought, something we resolve to do and pursue for a few months before the virtuous devotion to working out is undermined by a desire to sleep late. Yet exercise does not have to entail radical changes in habit. In this book, Harvey Simon, HMS associate professor of medicine at Massachusetts General Hospital, explains that while exercise is essential to good health, fitness needs vary from person to person, and exercise can usually fit into an individual’s existing routines. The No Sweat Exercise Plan includes a point system to identify the health benefits of everyday actions, such as gardening, climbing stairs, and walking; self-assessment tests to help evaluate one’s level of fitness; and health care tips.
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